The Minnes Lab - Bioelectromagnetism laboratory
Physics Department, Ariel University
"Only daring speculation can lead us further and not accumulation of facts.", Albert Einstein
Research
photodynamic therapy (PDT)
HNP (Harmonic Nanoparticle) – PS (photosensitizer) conjugate: using SHG (Second Harmonic Generation) for the improvement of PDT (Photo-Dynamic Therapy) treatment
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Developing an IR spectroscopic method to determine the metastatic potential of cancer cells
Using Attenuated Total Reflection - Fourier Transform Infra-Red (ATR-FTIR) spectroscopy to distinguish between melanoma cells with a different metastatic potential
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Developing an indirect method for analyzing the composition of urinary stone
Fiber-optic Evanescent Wave Spectroscopy (FEWS) of crystals from a urine sample as a tool for evaluating the chemical composition of kidney stones
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Ultra-high efficiency nanocrystal solar cells
A unique multi-layer device architecture to achieve ultra-high-efficiency nanocrystals solar cells.
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Exploring the mechanism of cell-cell interactions in nerve cells
Investigating the architecture of neural network to learn about the mechanism of cell-cell interactions in nerve cells
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Supercapacitors
Developement and chracterization of semiconducting nanomaterials and nanoarchitecture as supercapacitor electrode. Lab reserach having goal to design an electrode for high-performance supercapacitors using the layer-by-layer method.
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Particle Count Generator Program
software that, after identifying the particles in the image, evaluates the size of the particles and their size distribution (segmentation).
Learn MoreLab members
Michal Amar Sharon, Ph.D.
Lab Manager
Alina Sermiagin, Ph.D.
Postdoctoral researcher
Ayan Barbora, Ph.D.
Postdoctoral researcher
Svetlana Lyssenko
Ph.D. student
Girish Patil
Ph.D. student
Chandradip Jadhav
Ph.D. student
Samuel Abuh
Ph.D. student
Efrat Hochma
Ph.D. student
Manu Kumar
Master student
Inbar Dahari
Master student
Vadim Nave
Master student
Oren Boukobza
Master student
Lab alumni
Lakshmana Kumar Bommineedi, Ph.D.
Postdoctoral researcher
Publications
Articles
- Ayan Barbora, Sirish Karri, Michael A. Firer and Refael Minnes, 2023, "Multifractal analysis of cellular ATR-FTIR spectrum as a method for identifying and quantifying cancer cell metastatic levels" Scientific Reports, 13(1), 18935
- Roni Mina Hendler, Orly Eva Weiss, Tzachy Morad, Guy Sion, Michael Kirby, Zvy Dubinsky, Ayan Barbora, Refael Minnes and Danny Baranes, 2023, "A Poly-D-lysine-Coated Coralline Matrix Promotes Hippocampal Neural Precursor Cells’ Differentiation into GFAP-Positive Astrocytes" Polymers, 15(20), 4054.
- Asmita Dutta, Ortal Breuer, Manjunath Krishnappa, Refael Minnes, Alla Zak and Arie Borenstein, 2023, "1D transition-metal dichalcogenides/carbon core–shell composites for the hydrogen evolution reaction" Journal of Materials Chemistry A, 11(40), 21806.
- Ayan Barbora, Svetlana Lyssenko, Michal Amar, Vadim Nave, Vered Zivan, Lital Argaev Frenkel, Ariel Nause, Raichel Cohen-Harazi and Refael Minnes, 2023, "Optimizing the average distance between a blue light photosensitizer and a harmonic nanoparticle for effective infrared photodynamic therapy" Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 303, 123195.
- Ayan Barbora, Fares Yazbak, Svetlana Lyssenko, Vadim Nave, Faina Nakonechny, Paul Ben Ishai and Refael Minnes, 2022, "Second harmonic generation nanoparticles enables Near-Infrared Photodynamic Therapy from visible light reactive photosensitizer conjugates" PLoS One, 17(9).
- Zhanxiong Feng, Chandradip D. Jadhav, Girish P. Patil, Yun Wang, Zhiyong Jia, Vijay S. Baviskar, Refael Minnes and Chuang Zhang, 2022 “Solution processed 2D SnSe nanosheets catalysts: Temperature dependent Oxygen Reduction Reaction performance in alkaline media” – Journal of Electroanalytical Chemistry, 916, 116381.
- Inbar Dahari, Danny Baranes and Refael Minnes, 2021 “Automatic identification of dendritic branches and their orientation” – Journal of Visualized Experiments, 175.
- Ayan Barbora and Refael Minnes, 2021, "Targeted antiviral treatment using Non-ionizing Radiation Therapy for SARS-CoV-2 and viral pandemics preparedness: Technique, methods and practical notes for Clinical Application" PLoS One, 16(5).
- Ayan Barbora, Oryan Bohar, Ariel Alexander Sivan, Eyal Magory, Ariel Nause and Refael Minnes, 2021, "Higher Pulse Frequency of Near-Infrared Laser irradiation increases penetration depth for novel biomedical applications" PLoS One, 16(1).
- Tzachy Morad, Roni Mina Hendler, Eyal Canji, Orly Eva Weiss, Guy Sion, Refael Minnes, Ania Hava Grushchenko Polaq, Ido Merfeld, Zvy Dubinsky, Elimelech Nesher, and Danny Baranes, 2020, "Aragonite-Polylysine: Neuro-Regenerative Scaffolds with Diverse Effects on Astrogliosis." Polymers, 12(12).
- Ayala Gancz, Yekaterina Zueva, Orly Eva Weiss, Roni Mina Hendler, Refael Minnes and Danny Baranes, 2020, "Coralline Skeleton Biomaterial Reduces Phagocytosis in Mouse Blood in vitro." Israel Journal of Chemistry, 60(5-6), 586-592.
- Refael Minnes, Tamara Brider, Andrey Goryachev, Anna Grushchenko, Ruth Tor, Amichai Nevo, David Lifshitz, Abraham Katzir and Yosef Raichlin, 2019, "Fiber-optic Evanescent Wave Spectroscopy (FEWS) of Crystals from a Urine Sample as a Tool for Evaluating the Chemical Composition of Kidney Stones." Analytical Methods, 11(18), 2404-2409.
- Tzachy I. Morad, Roni Mina Hendler, Orly Eva Weiss, Eyal Aviv Canji, Ido Merfeld, Zvy Dubinsky, Refael Minnes, Yitshak I. Francis and Danny Baranes, 2019, "Gliosis of Astrocytes Cultivated on Coral Skeleton Is Regulated by the Matrix Surface Topography." Biomedical Materials, 14(4).
- Gilad, Y., H. Tuchinsky, G. Ben-David, R. Minnes, A. Gancz, H. Senderowitz, G. Luboshits, M.a. Firer, and G. Gellerman, 2017, "Discovery of Potent Molecular Chimera (CM358) to Treat Human Metastatic Melanoma." European Journal of Medicinal Chemistry, 138, 602-15.
- Refael Minnes, Mati Nissinmann, Yael Maizels, Gabi Gerlitz, Abraham Katzir, and Yosef Raichlin, 2017, "Using Attenuated Total Reflection–Fourier Transform Infra-Red (ATR-FTIR) Spectroscopy to Distinguish between Melanoma Cells with a Different Metastatic Potential." Scientific Reports, 7(1), 4381.
- Kathleen Scheffler, Refael Minnes, Vincent Fraisier, Anne Paoletti and Phong T. Tran, 2015, “Microtubule minus end motors kinesin-14 and dynein drive nuclear congression in parallel pathways” Journal of Cell Biology, 209, 47-58, # of citations: 12.
- Hagit Kun, Refael Minnes and Yitzhak Mastai, 2008, “Effects antifreeze peptides on the thermotropic properties of a model membrane”, Journal of Bioenergetics and Biomembranes, 40 (4), 389-396.
- Refael Minnes, Shany Ytzhak, Hana Weitman and Benjamin Ehrenberg, 2008, “The effect of solution electrolytes on the uptake of photosensitizers by liposomal membranes: a salting-out effect” Chemistry and Physics of Lipids, 155 (1), 38-42.
- Refael Minnes, Hana Weitman, Youngjae You, Michael R. Detty and Benjamin Ehrenberg, 2008, “Dithiaporphyrin derivatives as photosensitizers in membranes and cells” Journal of Physical Chemistry B, 112 (10), 3268-3276.
- Refael Minnes, Hana Weitman, and Benjamin Ehrenberg, 2007, “The effect of lipid composition, bilayer phase and temperature on the uptake of hematoporphyrin by liposomal membranes” Journal of Porphyrins and Phthalocyanines, 11 (08).
- Refael Minnes, Hana Weitman, Hyun-Jin Lee, Sergiu M. Gorun and Benjamin Ehrenberg, 2006, “Enhanced acidity, photophysical properties and liposome binding of perfluoroalkylated phthalocyanines lacking C-H bonds” Photochemistry and Photobiology, 82 (2), 593-599.
Book Chapters
- Lakshmana Kumar Bommineedi, Nakul Upadhyay and Refael Minnes, 2023 "Screen Printing: An Ease Thin Film Technique." In: Babasaheb R. Sankapal, Ahmed Ennaoui, Ram B. Gupta and Chandrakant D. Lokhande, editors. Simple Chemical Methods for Thin Film Deposition: Synthesis and Applications, Springer Nature.
- Tzachy Morad, Roni Mina Hendler, Eyal Canji, Orly Eva Weiss, Guy Sion, Refael Minnes, Ania Hava Grushchenko Polaq, Ido Merfeld, Zvy Dubinsky, Elimelech Nesher, and Danny Baranes, 2021 "Aragonite-Polylysine: Neuro-Regenerative Scaffolds with Diverse Effects on Astrogliosis." In: Monica Trif and Alexandru Vasile Rusu, editors. Prime Archive in Polymer Technology, Hyderabad, India: Vide Leaf.
Open positions
Ph.D. student
The Bio-electromagnetism Laboratory under the supervision of Dr. Refael Minnes is looking for a PhD student in the field of medical physics. The focus of the project is to use Second Harmonic Generation (SHG) to improve Photodynamic therapy (PDT), a treatment of various diseases and especially cancer.
Requirements
- You should have a MSc degree in physics, chemistry or biology. Experience in spectroscopic methods, image processing, programming and/or statistics is advantageous
- You are ready to work in an interdisciplinary environment
- You are interested in applying physical methods in biological and medical research.
- You are fluent in English, both in writing and speaking
- You have an independent and practical personality and ability to take initiatives
Bonuses
We are a multidisciplinary research team exploring the interactions of electromagnetic waves, specifically in the UV-Vis-IR range, with biological tissues and cells.
All opportunities a university department can offer such as scientific collaboration, education and training are available.
For additional information about a Ph.D. at the Ariel University, please visit:
https://www.ariel.ac.il/wp/graduate-school/en/#.
Please send your complete application electronically to Dr. Refael Minnes. We request a letter of motivation, and your CV plus transcripts of BSc, MSc grades or equivalent.
All opportunities a university department can offer such as scientific collaboration, education and training are available.
For additional information about a Ph.D. at the Ariel University, please visit:
https://www.ariel.ac.il/wp/graduate-school/en/#.
Please send your complete application electronically to Dr. Refael Minnes. We request a letter of motivation, and your CV plus transcripts of BSc, MSc grades or equivalent.
Post-Doc researcher
The Bio-electromagnetism Laboratory under the supervision of Dr. Refael Minnes is looking for a Post-Doc researcher in the field of medical physics. The post-doc will use UV-Vis-IR spectroscopic methods with biological tissues and cells.
Requirements
- You should have a Ph.D. degree in physics, chemistry or biology with experience in spectroscopic methods.
- Experience in photodynamic therapy (PDT) is an advantage.
- You are ready to work in an interdisciplinary environment.
- You are interested in applying physical methods in biological and medical research.
- You are fluent in English, both in writing and speaking
- You have an independent and practical personality and ability to take
Bonuses
We are a multidisciplinary research team exploring the interactions of electromagnetic waves, specifically in the UV-Vis-IR range, with biological tissues and cells.
All opportunities a university department can offer such as scientific collaboration, education and training are available.
For additional information about an employment at the Ariel University, please visit https://www.ariel.ac.il/wp/graduate-school/en/#.
Please send your complete application electronically to Dr. Refael Minnes. We request a letter of motivation, and your CV plus transcripts of BSc, MSc and PhD grades or equivalent.
All opportunities a university department can offer such as scientific collaboration, education and training are available.
For additional information about an employment at the Ariel University, please visit https://www.ariel.ac.il/wp/graduate-school/en/#.
Please send your complete application electronically to Dr. Refael Minnes. We request a letter of motivation, and your CV plus transcripts of BSc, MSc and PhD grades or equivalent.
Ph.D. student
The Bio-electromagnetism Laboratory under the supervision of Dr. Refael Minnes is looking for a Ph.D. student in the field of medical physics. In this project we intend to develop a new technique that will allow us to visualize cancer cells according to their metastatic level.
Requirements
- You should have a master degree in physics, chemistry or biology with experience in spectroscopic methods.
- Experience in FTIR microscopy is an advantage.
- You are ready to work in an interdisciplinary environment.
- You are interested in applying physical methods in biological and medical research.
- You are fluent in English, both in writing and speaking
- You have an independent and practical personality and ability to take initiatives
Bonuses
We are a multidisciplinary research team exploring the interactions of electromagnetic waves, specifically in the UV-Vis-IR range, with biological tissues and cells. All opportunities a university department can offer such as scientific collaboration, education and training are available.
For additional information about a Ph.D. at the Ariel University, please visit:
https://www.ariel.ac.il/wp/graduate-school/en/#.
Please send your complete application electronically to Dr. Refael Minnes. We request a letter of motivation, and your CV plus transcripts of BSc, MSc grades or equivalent.
For additional information about a Ph.D. at the Ariel University, please visit:
https://www.ariel.ac.il/wp/graduate-school/en/#.
Please send your complete application electronically to Dr. Refael Minnes. We request a letter of motivation, and your CV plus transcripts of BSc, MSc grades or equivalent.
